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2020•Carolina Digital Repository (University of North Carolina at Chapel Hill)Open access

A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine

Mackenzie Leigh Cottrell, Nicole White, Kristine B. Patterson, Jacob E. Wulff, Heather M. A. Prince, Evan S. Dellon, Angela D. M. Kashuba, Kuo H. Yang, Ryan D. Madanick, Nicholas J. Shaheen, Stephanie A. Malone, Craig Sykes, Julie A. E. Nelson, Michael G. Hudgens

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Abstract

Background. A novel translational pharmacology investigation was conducted by combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical modeling to determine the number of doses required for effective human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP).

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Background. A novel translational pharmacology investigation was conducted by combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical modeling to determine the number of doses required for effective human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP).

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Available abstract

Background. A novel translational pharmacology investigation was conducted by combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical modeling to determine the number of doses required for effective human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP).

Key concepts: Emtricitabine, Tenofovir, Pre-exposure prophylaxis, Human immunodeficiency virus (HIV), Medicine, Pharmacology, Virology, Antiretroviral therapy

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A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine — Research Paper | ScholarLens