2022•Biochemical PharmacologyOpen access

Development of a biomarker to monitor target engagement after treatment with dihydroorotate dehydrogenase inhibitors

Michael A. Pontikos, Christopher Leija, Zhiyu Zhao, Xiaoyu Wang, Jessica A. Kilgore, Belén Tornesi, Nicole Adenmatten, Margaret A. Phillips, Noelle S. Williams

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Key concepts: Dihydroorotate dehydrogenase, Pyrimidine metabolism, Teriflunomide, Pharmacology, Plasmodium falciparum, Biomarker, Toxicity, Chemistry

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Development of a biomarker to monitor target engagement after treatment with dihydroorotate dehydrogenase inhibitors — Research Paper | ScholarLens