Efficacy of ondansetron alone, dexamethasone alone and combination of ondansetron and dexamethasone for PONV for patients undergoing under general anaesthesia

Aim: To compare the efficacy of Ondansetron alone, Dexamethasone alone and combination of Ondansetron and Dexamethasone for postoperative nausea and vomiting for patients undergoing elective surgeries under general anaesthesia. Materials and methods: A prospective randomized comparative study in Ninety patients (of either sex belonging to ASA I and II physical status) posted for elective surgeries (under General Anaesthesia) were selected and were randomly allocated into three groups; Dexamethasone (Group A) alone, Ondansetron (Group B), and Dexamethasone and Ondansetron (Group C). Results: There was no significant difference in the baseline parameters among the groups Intra-operatively and post-operatively, we did not observe any statistically significant differences within or between the groups. The results of our study revealed that patients receiving Ondansetron and Dexamethasone had significantly lesser incidence of PONV when compared with either Dexamethasone alone or Ondansetron alone during the first 24 hours postoperative period. The incidence of PONV was 13.2%, 18.98%, and 36.3% respectively In our study, the complete response occurred in 86.8% of the cases in Dexamethasone and Ondansetron combination group, 81.02% in Dexamethasone alone group and 63.7% in Ondansetron alone group.