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2022•Research SquareOpen access

Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus

Dong‐Hwi Kim, Sang-Hoon Han, Hyeon‐Jeong Go, Da-Yoon Kim, Jae-Hyeong Kim, Joong-Bok Lee, Seung‐Yong Park, Chang‐Seon Song, Sangwon Lee, In‐Soo Choi

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Abstract

Abstract Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithelial cells. This study aimed at investigating the antiviral activity of Ad-caIFNλ3 against CCoV, CPV, and CDV in two canine cell lines, A72 and MDCK. Ad-caIFNλ3 transduction suppressed replication of these viruses without cytotoxicity. These results suggested that Ad-caIFNλ3 may be a therapeutic candidate for canine viral diseases.

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Abstract Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithelial cells. This study aimed at investigating the antiviral activity of Ad-caIFNλ3 against CCoV, CPV, and CDV in two canine cell lines, A72 and MDCK. Ad-caIFNλ3 transduction suppressed replication of these viruses without cytotoxicity. These results suggested that Ad-caIFNλ3 may be a therapeutic candidate for canine viral diseases.

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Available abstract

Abstract Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithelial cells. This study aimed at investigating the antiviral activity of Ad-caIFNλ3 against CCoV, CPV, and CDV in two canine cell lines, A72 and MDCK. Ad-caIFNλ3 transduction suppressed replication of these viruses without cytotoxicity. These results suggested that Ad-caIFNλ3 may be a therapeutic candidate for canine viral diseases.

Key concepts: Canine parvovirus, Canine distemper, Virology, Parvovirus, Virus, Interferon, Biology, Recombinant DNA

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Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus — Research Paper | ScholarLens