2000•Ullmann's Encyclopedia of Industrial ChemistryRequires access
Peptide Synthesis
Wolfgang Heinzel, Michael S. Verlander
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Abstract
The article contains sections titled: 1. Introduction 2. Fundamentals of Peptide Synthesis 3. Protecting Groups 3.1. Amine Protecting Groups 3.2. Carboxyl Protecting Groups 3.3. Sulfhydryl Protecting Groups 3.4. Hydroxyl Protecting Groups 3.5. Imidazole Protecting Groups 3.6. Protecting Groups for Guanidine 3.7. Other Protecting Groups 4. Formation of the Peptide Bond 4.1. Active Ester Method 4.2. Anhydride Method 4.3. Azide Method 4.4. Carbodiimide Method 5. Strategies for Peptide Synthesis 5.1. Synthesis in Solution 5.2. Solid-Phase Synthesis 5.3. Other Synthetic Methods 5.3.1. Liquid-Phase Synthesis 5.3.2. Semisynthesis 5.3.3. Enzymatic Synthesis 5.3.4. Recombinant DNA-Based Synthesis 5.3.5. Concluding Remarks 6. Cleavage of Protecting Groups 7. Purification of Peptides 8. Analytical Control of Peptides 9. Important Commercial Peptides