2008•Wiley Encyclopedia of Chemical BiologyRequires access
Enzyme Inhibition
Richard B. Silverman
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Abstract
Abstract This article describes various approaches to inhibition of enzyme catalysis. Reversible inhibition includes competitive, uncompetitive, mixed inhibition, noncompetitive inhibition, transition state, and slow tight‐binding inhibition. Irreversible inhibition approaches include affinity labeling and mechanism‐based enzyme inhibition. The kinetics of the various inhibition approaches are summarized, and examples of each type of inhibition are presented.