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1995•Molecular PharmacologyRequires access

Inhibition of human 5-phosphoribosyl-1-pyrophosphate synthetase by 4-amino-8-(beta-D-ribofuranosylamino)-pyrimido[5,4-d]pyrimidine-5'- monophosphate: evidence for interaction at the ADP allosteric site.

David W. Fry, Michael A. Becker, Robert L. Switzer

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Key concepts: Uncompetitive inhibitor, Non-competitive inhibition, Allosteric regulation, Pyrophosphate, Chemistry, Mixed inhibition, IC50, Enzyme

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Inhibition of human 5-phosphoribosyl-1-pyrophosphate synthetase by 4-amino-8-(beta-D-ribofuranosylamino)-pyrimido[5,4-d]pyrimidine-5'- monophosphate: evidence for interaction at the ADP allosteric site. — Research Paper | ScholarLens