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Effect of Ribocitrin on Glucan Synthesizing Enzymes ofStreptococcus mutansE49

Masachika Takashio, Yoshirō Okami

Abstract

Enzymes participating in glucan synthesis by Streptococcus mutans E49 were separated into two fractions with distinctly different activities by chromatography on DEAE Bio-Gel A. The insoluble glucan (IG) was revealed to be formed by the coupling reaction of these two enzymes, dextransucrase (SGE), which synthesizes soluble glucan from sucrose, and a glucan insolubilizing enzyme (IGE), which forms IG from soluble glucan. Ribocitrin was found to inhibit IG synthesis by inhibiting SGE.

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Key concepts: Streptococcus mutans, Dextransucrase, Glucan, Chemistry, Enzyme, Sucrose, Biochemistry, Glucosyltransferases