ScholarLens Back to search
1964•Drug and Therapeutics BulletinRequires access

Hypertensive attacks with MAO inhibitors

Author information unavailable

Open publisher page 0 citations

Abstract

Some months ago we drew attention to the attacks of severe hypertension which can occur in patients taking monoamine oxidase (MAO) inhibitors (Drug & Therap. Bull. 1963, 1, 44). Most cases have been due to tranylcypromine1 (Parnate - SKF) with which an incidence of up to 20% is now reported2, but in others phenelzine3 (Nardil - Warner), nialamide4 (Niamid - Pfizer) or iproniazid5 (Marsilid - Roche) have been responsible. Both the frequency and severity of the reaction have been seriously underestimated; it may cause subarachnoid haemorrhage or acute cardiac failure. The duration of treatment and dosage vary considerably.

About this research paper

What this paper is about

Some months ago we drew attention to the attacks of severe hypertension which can occur in patients taking monoamine oxidase (MAO) inhibitors (Drug & Therap. Bull. 1963, 1, 44). Most cases have been due to tranylcypromine1 (Parnate - SKF) with which an incidence of up to 20% is now reported2, but in others phenelzine3 (Nardil - Warner), nialamide4 (Niamid - Pfizer) or iproniazid5 (Marsilid - Roche) have been responsible. Both the frequency and severity of the reaction have been seriously underestimated; it may cause subarachnoid haemorrhage or acute cardiac failure. The duration of treatment and dosage vary considerably.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Some months ago we drew attention to the attacks of severe hypertension which can occur in patients taking monoamine oxidase (MAO) inhibitors (Drug & Therap. Bull. 1963, 1, 44). Most cases have been due to tranylcypromine1 (Parnate - SKF) with which an incidence of up to 20% is now reported2, but in others phenelzine3 (Nardil - Warner), nialamide4 (Niamid - Pfizer) or iproniazid5 (Marsilid - Roche) have been responsible. Both the frequency and severity of the reaction have been seriously underestimated; it may cause subarachnoid haemorrhage or acute cardiac failure. The duration of treatment and dosage vary considerably.

Key concepts: Tranylcypromine, Nialamide, Phenelzine, Iproniazid, Monoamine oxidase, Medicine, Monoamine oxidase inhibitor, Incidence (geometry)

Related papers

Related paper 1Related paper 2
Back to paper searchBrowse research topicsOriginal source
Hypertensive attacks with MAO inhibitors — Research Paper | ScholarLens