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The effect of nialamide, pargyline and tranylcypromine on the removal of amphetamine by the perfused liver

Fedora R Trinker, M. J. Rand

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Abstract

Abstract Nialamide, pargyline and tranylcypromine, three monoamine oxidase inhibiting drugs, and the microsomal enzyme inhibitor SKF 525-A significantly decreased the amount of amphetamine removed from the portal circulation of the isolated perfused liver of the cat. The enhancement of the vascular actions and toxicity of amphetamine by monoamine oxidase inhibitors could be explained in terms of these findings.

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What this paper is about

Abstract Nialamide, pargyline and tranylcypromine, three monoamine oxidase inhibiting drugs, and the microsomal enzyme inhibitor SKF 525-A significantly decreased the amount of amphetamine removed from the portal circulation of the isolated perfused liver of the cat. The enhancement of the vascular actions and toxicity of amphetamine by monoamine oxidase inhibitors could be explained in terms of these findings.

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Available abstract

Abstract Nialamide, pargyline and tranylcypromine, three monoamine oxidase inhibiting drugs, and the microsomal enzyme inhibitor SKF 525-A significantly decreased the amount of amphetamine removed from the portal circulation of the isolated perfused liver of the cat. The enhancement of the vascular actions and toxicity of amphetamine by monoamine oxidase inhibitors could be explained in terms of these findings.

Key concepts: Nialamide, Tranylcypromine, Pargyline, Monoamine oxidase, Amphetamine, Monoamine oxidase inhibitor, Iproniazid, Chemistry

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