2010•Biophysical JournalOpen access

Multiple Mechanisms of hERG Liability: K+ Current Inhibition, Disruption of Protein Trafficking, and Apoptosis Induced by Amoxapine

Sabrina Obers, Ingo Staudacher, Ramona Bloehs, Eckhard Ficker, Adrienne T. Dennis, Jana Kisselbach, Patrick A. Schweizer, Ioana Bâldea, Hugo Katus, Dierk Thomas

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Key concepts: hERG, Potassium channel blocker, Pharmacology, Potassium channel, Chemistry, Patch clamp, HEK 293 cells, Biophysics

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Multiple Mechanisms of hERG Liability: K+ Current Inhibition, Disruption of Protein Trafficking, and Apoptosis Induced by Amoxapine — Research Paper | ScholarLens