2005•Unpublished venueRequires access
HERG potassium channel and drug evaluation
Zheng Jian
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Abstract
The K~(+) channel encoded by the human et her——go-go related gene(HERG) plays a very important role in human physiolo gical and pathological processes. HERG potassium channel determines the outward currents which facilitate the repolarization of the myocardial cells. Blockade o f HERG channel usually results in a long QT interval and serious arrhythmia. Thu s, HERG potassium channel has become a valuable target for screening leading com pounds for QT interval prolongation in drug development program.