Enzyme Inhibition
Paul F. Hollenberg
Abstract
Paul F. Hollenberg
Abstract
This chapter contains sections titled: Introduction Mechanisms of Enzyme Inhibition Competitive Inhibition Noncompetitive Inhibition Uncompetitive Inhibition Product Inhibition Transition-State Analogs Slow, Tight-Binding Inhibitors Mechanism-Based Inactivators Inhibitors That Are Metabolized to Reactive Products That Covalently Attach to the Enzyme Substrate Inhibition Partial Inhibition Inhibition of Cytochrome P450 Enzymes Reversible Inhibitors Quasi-Irreversible Inhibitors Mechanism-Based Inactivators References
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This chapter contains sections titled: Introduction Mechanisms of Enzyme Inhibition Competitive Inhibition Noncompetitive Inhibition Uncompetitive Inhibition Product Inhibition Transition-State Analogs Slow, Tight-Binding Inhibitors Mechanism-Based Inactivators Inhibitors That Are Metabolized to Reactive Products That Covalently Attach to the Enzyme Substrate Inhibition Partial Inhibition Inhibition of Cytochrome P450 Enzymes Reversible Inhibitors Quasi-Irreversible Inhibitors Mechanism-Based Inactivators References
Key concepts: Non-competitive inhibition, Uncompetitive inhibitor, Enzyme, Enzyme inhibition, Chemistry, Product inhibition, Mixed inhibition, Biochemistry