ScholarLens Back to search
1967•Clinical Pharmacology & TherapeuticsRequires access

Assessment of the dependence‐producing properties of dihydrocodeinone and codoxime

Donald R. Jasinski, William R. Martin

Open publisher page 10 citations

Abstract

Dihydrocodeinone and a new narcotic antitussive, codoxime, were compared in single doses with morphine in a crossover study to compare their ability to produce opiate‐like euphoria. In addition, both drugs were substituted for morphine in 7 chronically addicted subjects to determine their capacity to produce physical dependence. Results indicated both drugs definitely produced drug dependence of the morphine type.

About this research paper

What this paper is about

Dihydrocodeinone and a new narcotic antitussive, codoxime, were compared in single doses with morphine in a crossover study to compare their ability to produce opiate‐like euphoria. In addition, both drugs were substituted for morphine in 7 chronically addicted subjects to determine their capacity to produce physical dependence. Results indicated both drugs definitely produced drug dependence of the morphine type.

Why it matters

OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Dihydrocodeinone and a new narcotic antitussive, codoxime, were compared in single doses with morphine in a crossover study to compare their ability to produce opiate‐like euphoria. In addition, both drugs were substituted for morphine in 7 chronically addicted subjects to determine their capacity to produce physical dependence. Results indicated both drugs definitely produced drug dependence of the morphine type.

Key concepts: Euphoriant, Physical dependence, Morphine, Opiate, Narcotic, Narcotic antagonists, Pharmacology, Crossover study

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Assessment of the dependence‐producing properties of dihydrocodeinone and codoxime — Research Paper | ScholarLens