2021ARKIVOCOpen access

One-pot synthesis of stable phosphorus ylides by three-component reaction between arylglyoxals, phosphines and barbituric or Meldrum’s acid

Mahsa Latifi, Mohammad Anary‐Abbasinejad

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Abstract

An efficient one-pot method for the synthesis of new substituted phosphorus ylides is described via threecomponent reaction between arylglyoxals, C-H acids such as barbituric acid and Meldrum's acid and triphenylphosphine or tri-n-octylphosphine.This reaction was carried out in boiling ethanol in the absence of any catalyst to afford the products in good to excellent yields.

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An efficient one-pot method for the synthesis of new substituted phosphorus ylides is described via threecomponent reaction between arylglyoxals, C-H acids such as barbituric acid and Meldrum's acid and triphenylphosphine or tri-n-octylphosphine.This reaction was carried out in boiling ethanol in the absence of any catalyst to afford the products in good to excellent yields.

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Available abstract

An efficient one-pot method for the synthesis of new substituted phosphorus ylides is described via threecomponent reaction between arylglyoxals, C-H acids such as barbituric acid and Meldrum's acid and triphenylphosphine or tri-n-octylphosphine.This reaction was carried out in boiling ethanol in the absence of any catalyst to afford the products in good to excellent yields.

Key concepts: Chemistry, Barbituric acid, Meldrum's acid, Component (thermodynamics), Organic chemistry, Phosphorus, Medicinal chemistry, Thermodynamics

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One-pot synthesis of stable phosphorus ylides by three-component reaction between arylglyoxals, phosphines and barbituric or Meldrum’s acid — Research Paper | ScholarLens