One-pot three-component reaction of arylglyoxals with acetylthiourea and Meldrum’s acid or barbituric acid for synthesis of new 2-acetamido-4-arylthiazol-5-yl derivatives
Farzaneh Alizadeh‐Bami, Hossein Mehrabi, Reza Ranjbar‐Karimi
Abstract
Farzaneh Alizadeh‐Bami, Hossein Mehrabi, Reza Ranjbar‐Karimi
Abstract
An efficient method for the synthesis of 2-acetamido-4-arylthiazol-5-yl derivatives via a novel one-pot three-component reaction of arylglyoxals, 1,3-dicarbonyl compounds such as Meldrum’s acid or barbituric acid, and acetylthiourea in ethanol is reported.
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An efficient method for the synthesis of 2-acetamido-4-arylthiazol-5-yl derivatives via a novel one-pot three-component reaction of arylglyoxals, 1,3-dicarbonyl compounds such as Meldrum’s acid or barbituric acid, and acetylthiourea in ethanol is reported.
Key concepts: Barbituric acid, Chemistry, Meldrum's acid, Component (thermodynamics), Organic chemistry, Ethanol, Medicinal chemistry, Thermodynamics