2015•Japanese Journal of Complementary and Alternative MedicineOpen access

Inhibitory and Inducing Effects of Astaxanthin on CYP

Hiroki Tsukahara, Tazuru KIKKAWA, Shinichi FUKUYAMA, Hoko KYO, Nobutaka Suzuki

Abstract

ヒト肝ミクロソームを用いて，CYP の 7 分子種（CYP1A2，CYP2B6，CYP2C8，CYP2C9，CYP2C19，CYP2D6 及び CYP3A4）に対するアスタキサンチンの阻害作用を検討したところ，通常の摂取量ではアスタキサンチンは CYP を阻害しなかった．また，ヒト凍結肝細胞を用いて，CYP の 3 分子種（CYP1A2，CYP2B6 及び CYP3A4）に対するアスタキサンチンの誘導作用を検討した結果，通常の摂取量ではアスタキサンチンは CYP を誘導しなかった．

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Available abstract

Key concepts: CYP2B6, CYP1A2, CYP3A4, CYP2C9, CYP2D6, CYP2C19, Chemistry, Pharmacology