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MEDULLARY CELL SUSPENSION FOR RADIATION INDUCED BONE MARROW DAMAGE

Theodor M. Fliedner

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Abstract

Inbred rats maintained at this institute were given 800 rep of radiation with 15 Mev electrons to the whole body. Immediately after irradiation the animals were injected intravenously with a suspension of bone marrow cells from unirradiated animals of the same strain. Compared to untreated control animals, there was a more rapid regeneration of the bone marrow beginning the third day after irradiation. Regeneration was more pronounced in the erythropoietic series; no significant acceleration of myelopoiesis resulted. The degree of hemorrhage noted on the third day after irradiation was less in the treated animals. The injected marrow did not affect the onset of marrow aplasia nor the circulatory changes seen within 24 hours of exposure.

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What this paper is about

Inbred rats maintained at this institute were given 800 rep of radiation with 15 Mev electrons to the whole body. Immediately after irradiation the animals were injected intravenously with a suspension of bone marrow cells from unirradiated animals of the same strain. Compared to untreated control animals, there was a more rapid regeneration of the bone marrow beginning the third day after irradiation. Regeneration was more pronounced in the erythropoietic series; no significant acceleration of myelopoiesis resulted. The degree of hemorrhage noted on the third day after irradiation was less in the treated animals. The injected marrow did not affect the onset of marrow aplasia nor the circulatory changes seen within 24 hours of exposure.

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Available abstract

Inbred rats maintained at this institute were given 800 rep of radiation with 15 Mev electrons to the whole body. Immediately after irradiation the animals were injected intravenously with a suspension of bone marrow cells from unirradiated animals of the same strain. Compared to untreated control animals, there was a more rapid regeneration of the bone marrow beginning the third day after irradiation. Regeneration was more pronounced in the erythropoietic series; no significant acceleration of myelopoiesis resulted. The degree of hemorrhage noted on the third day after irradiation was less in the treated animals. The injected marrow did not affect the onset of marrow aplasia nor the circulatory changes seen within 24 hours of exposure.

Key concepts: Bone marrow, Medullary cavity, Myelopoiesis, Regeneration (biology), Haematopoiesis, Pathology, Aplasia, Medicine

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