1959•OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)Requires access
THE EFFECTS OF SPLEEN HOMOGENATE ON RADIOINDUCED BONE MARROW DAMAGE
Heather Thom
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Abstract
Inbreed rats received a whole-body irradiation of 800 rep 15 Mev electrons and were subsequently treated by 2 injections of 0.5 ml homogenate obtained from 150 x 10/sup 6/ spleen cells from healthy animals of the same breed. The first injection was given I.V. right after the irradiation. The second injection was given at the 3rd day after irradiation intraperitoneally. As compared with the untreated control animals the regeneration of the bone marrow was more rapidly, which was observed qualitative histological as well as quantitative cytological. The initial phase of damage was not changed. Already at the 3rd day after irradiation the first signs of regeneration were observed. A complete restitution wag found after 14 days as compared with 21 days in the untreated control animals. The increased regeneration of the bone marrow by spleen homogenate is most significant in the erythropoesis, less marked in the myelopoesis. (auth)