Use of Intralesional Sodium Thiosulfate for Treating Recurrent Calciphylaxis

Calciphylaxis is a rare and life-threatening disorder characterized by painful skin ulceration. Intravenous sodium thiosulfate has proven effective for calciphylaxis treatment; however, its use is associated with risk of complications, potentially necessitating hospitalization. Herein, we describe the case of a patient with calciphylaxis who experienced recurrence approximately 5 months after healing with a combination therapy of intralesional/intravenous sodium thiosulfate. We successfully treated the recurrent ulcers in outpatient care with intralesional sodium thiosulfate, which reportedly has few side effects. Although intravenous sodium thiosulfate administration is the first-line treatment for calciphylaxis, intralesional administration seems to be a reasonable alternative for injectable small lesions, even in recurrent cases.