Combination of Intravenous and Intralesional Sodium Thiosulfate for the Treatment of Calciphylaxis

Calciphylaxis is a rare and life-threatening disorder characterized by painful skin ulceration. Treatment is not yet standardized; however, a case of calciphylaxis successfully treated by intravenous sodium thiosulfate was reported in 20041). Since then, several reports have supported the use of sodium thiosulfate in the treatment of calciphylaxis. However, intravenous administration of sodium thiosulfate may be limited owing to its systemic side effects. We report the successful treatment of a female patient with intractable right-leg calciphylaxis who was administered both intravenous and intralesional sodium thiosulfate combination therapy without side effects.