2021•Tobacco Regulatory ScienceOpen access
Effect of Salvia Miltiorrhiza Polyphenolic Acid Combined with Salvia Miltiorrhiza Ligustrazine Injection on Cognitive Function in Patients with Cerebral Infarction
Wei Hua, Qi Tang, MinHua Kuang, HaiRong Cai, Jiajian Peng, Yingying Li
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Abstract
Objective: To investigate the effect of salvia miltiorrhiza polyphenolic acid combined with salvia miltiorrhiza ligustrazine injection on cognitive function in patients with cerebral infarction. Methods: 60 patients with cerebral infarction from December 2017 to December 2019 were randomly divided into control group (n = 30) and observation group (n = 30) by random number table method. The control group was treated with salvia miltiorrhiza ligustrazine injection, and the observation group was treated with salvia miltiorrhiza polyphenolic acid on the basis of the control group. After 4-week treatment, the effect of the patients was evaluated, and the hemorheological level, cognitive function and drug safety of the two groups were compared. Results: The levels of high blood and low shear viscosity, high whole blood and plasma viscosity in the observation group were lower than those in the control group 4 weeks after treatment (P<0.05); the cognitive function scores in the observation group were higher than those in the control group 2 and 4 weeks after treatment (P<0.05); the incidence rates of liver and kidney function damage, mild diarrhea, dizziness and somnolence, nausea and vomiting, and blood pressure fluctuation in the treatment of the two groups had no statistical significance (P>0.05). Conclusion: The combination of salvia miltiorrhiza polyphenolic acid and salvia miltiorrhiza ligustrazine injection can improve the hemorheology of patients with cerebral infarction. It is helpful to improve the cognitive function of patients. The drug is safe and worthy of being popularized.