2021•PubMedOpen access

Added Diagnostic Value of Cerebrospinal Fluid Carcinoembryonic Antigen in a Patient with Leptomeningeal Carcinomatosis as the Initial Manifestation of Gastric Cancer.

Riku Ino, Ken‐ei Sada, Atsushi Miyauchi, Daisuke Hashimoto, Shigeru Nojima, Shingo Yamanaka, Masafumi Kawamura

Abstract

A 77-year-old woman with no history of malignancy presented with anorexia and bilateral lower extremity weakness. Her consciousness level worsened daily, so we performed a lumbar puncture. Cerebrospinal fluid (CSF) analysis indicated meningitis, but three rounds of CSF cytology showed no malignant cells. The patient's carcinoembryonic antigen (CEA) level was highly elevated in CSF, but normal in serum. Through gadolinium-enhanced brain/spinal magnetic resonance imaging and gastrointestinal endoscopy, she was diagnosed with leptomeningeal carcinomatosis (LC) from gastric cancer. CEA level in CSF facilitated the diagnosis of LC from gastric cancer because there were no malignant cells on CSF cytology.

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Key concepts: Medicine, Carcinoembryonic antigen, Cerebrospinal fluid, Malignancy, Meningeal carcinomatosis, Lumbar puncture, Cancer, Pathology