2021•Microbiology SpectrumOpen access

In Vitro Efficacy of Gentamicin Alone and in Combination with Ceftriaxone, Ertapenem, and Azithromycin against Multidrug-Resistant Neisseria gonorrhoeae

Xuechun Li, Wenjing Le, Xiangdi Lou, Biwei Wang, Caroline A. Genco, Peter A. Rice, Xiaohong Su

Abstract

susceptibility against clinical gonococcal isolates collected in 2016 and 2017, including MDR isolates. Combinations of gentamicin plus ertapenem, ceftriaxone, and azithromycin produced synergistic effects against certain MDR isolates. No antagonism was observed in any of the antimicrobial combinations, which may prove useful to guide clinical testing of combination therapies.

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Key concepts: Ertapenem, Microbiology, Ceftriaxone, Gentamicin, Neisseria gonorrhoeae, Agar dilution, Etest, Minimum inhibitory concentration