Study on the Relationship between Ambulatory Blood Pressure and Left Ventricular Hypertrophy and Renal Function in Hypertension

Objective To study the relationship between 24-hour ambulatory blood pressure(ABP) and left ventricular hypertrophy(LVH)and renal function.Methods 52 hypertension patients were studied through 24-hour ABP,echocardiography,renal function and routine urine test.All the patients were divided into normal blood pressure control group and abnormal blood pressure group,normal daytime blood pressure group and abnormal daytime blood pressure group,normal nighttime blood pressure group and abnormal nighttime blood pressure group,dipper and non-dipper group,LVH and non-LVH group.Echocardiography,renal function and ABP parameters were compared in these groups.Results IVST,PWT and LVM were significantly higher in abnormal blood pressure group,abnormal daytime blood pressure group and abnormal nighttime blood pressure group than those in normal group.LVMI were significantly higher in abnormal blood pressure group and abnormal nighttime blood pressure group than those in normal group(P 0.05).LVDd,LVM and LVMI were higher in non-dipper group versus dipper group,but the differences were not significant(P 0.05).24 h-SBP and nSBP were significantly higher in LVH group compared to non-LVH group(P 0.05).Urinary protein was found to be positively correlated with 24h-SBP through bivariate correlation analysis(r = 0.443,P = 0.001).Conclusion Nocturnal blood pressure,especially systolic blood pressure level in hypertension patients,was closely related with target organ damages such as left ventricular hypertrophy and impairment of renal function.