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2006•The Professional Medical JournalOpen access

BREAST CANCER

Mumtaz Begum, Ghazala Ruby, RUKHASHAN KHURSHID, Saleem Akhtar

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Abstract

CA 15.3 is a useful parameter in the management of patients in different stages ofthe breast cancer. Objectives: (1) To evaluate the level of CA 15-3 in stage III carcinoma of breast. (2) To study therole of immunoglobulin G and cathepsin D. Patients & Methods: Serum CA 15-3 was assayed in a group of 25 femalebreast cancer patients with stage III. Method used for determination of CA 15-3 is IMMULITE Automated ImmunoassaySystem. Result: 25 patients were taken in the study. It was observed that the level of CA 15-3 and cathepsin D issignificantly increased in patients as compared to control subjects. Although the level of IgG was also increased butit shows no significant difference. Conclusion: It is concluded that CA 15-3 can be used as tumor marker especiallyin the 3 stage rd of breast cancer and also for monitoring the treatment. IgG shows the role of body defense mechanismsystem in breast cancer. Whereas protease like cathepsin D shows the extent of metastasis.

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CA 15.3 is a useful parameter in the management of patients in different stages ofthe breast cancer. Objectives: (1) To evaluate the level of CA 15-3 in stage III carcinoma of breast. (2) To study therole of immunoglobulin G and cathepsin D. Patients & Methods: Serum CA 15-3 was assayed in a group of 25 femalebreast cancer patients with stage III. Method used for determination of CA 15-3 is IMMULITE Automated ImmunoassaySystem. Result: 25 patients were taken in the study. It was observed that the level of CA 15-3 and cathepsin D issignificantly increased in patients as compared to control subjects. Although the level of IgG was also increased butit shows no significant difference. Conclusion: It is concluded that CA 15-3 can be used as tumor marker especiallyin the 3 stage rd of breast cancer and also for monitoring the treatment. IgG shows the role of body defense mechanismsystem in breast cancer. Whereas protease like cathepsin D shows the extent of metastasis.

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Available abstract

CA 15.3 is a useful parameter in the management of patients in different stages ofthe breast cancer. Objectives: (1) To evaluate the level of CA 15-3 in stage III carcinoma of breast. (2) To study therole of immunoglobulin G and cathepsin D. Patients & Methods: Serum CA 15-3 was assayed in a group of 25 femalebreast cancer patients with stage III. Method used for determination of CA 15-3 is IMMULITE Automated ImmunoassaySystem. Result: 25 patients were taken in the study. It was observed that the level of CA 15-3 and cathepsin D issignificantly increased in patients as compared to control subjects. Although the level of IgG was also increased butit shows no significant difference. Conclusion: It is concluded that CA 15-3 can be used as tumor marker especiallyin the 3 stage rd of breast cancer and also for monitoring the treatment. IgG shows the role of body defense mechanismsystem in breast cancer. Whereas protease like cathepsin D shows the extent of metastasis.

Key concepts: Medicine, Breast cancer, Cathepsin D, Stage (stratigraphy), Internal medicine, Cancer, Breast carcinoma, Oncology

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