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1995•Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical ScienceOpen access

SYNTHESIS AND REACTIONS OF 1,2-4,4 (BIS-1(2H)-PHTHALAZINOYL) ETHANE

Ahmed Foud El-Farargy, Somaya Abd El-Rahman, Abd El‐Fattah Z. Haikal, Essam Abd El-Ghani, Ahmed Shahin

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Abstract

Phthalic anhydride reacted with succinic acid in presence of potassium acetate to give compound 1 which reacted with two moles of hydrazine hydrate to give the new compound 1,2-4,4` (bis-1(2H)-phthalazinoyl) ethane 2. The behaviour of compound 2 towards different carbon electrophiles and carbon nucleophiles has been described.

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What this paper is about

Phthalic anhydride reacted with succinic acid in presence of potassium acetate to give compound 1 which reacted with two moles of hydrazine hydrate to give the new compound 1,2-4,4` (bis-1(2H)-phthalazinoyl) ethane 2. The behaviour of compound 2 towards different carbon electrophiles and carbon nucleophiles has been described.

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Available abstract

Phthalic anhydride reacted with succinic acid in presence of potassium acetate to give compound 1 which reacted with two moles of hydrazine hydrate to give the new compound 1,2-4,4` (bis-1(2H)-phthalazinoyl) ethane 2. The behaviour of compound 2 towards different carbon electrophiles and carbon nucleophiles has been described.

Key concepts: Phthalic anhydride, Hydrazine (antidepressant), Electrophile, Succinic anhydride, Hydrate, Nucleophile, Chemistry, Medicinal chemistry

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