ASSOCIATION BETWEEN TRANSIENT TACHYPNEA OF THE NEWBORN AND WHEEZING SYMPTOMS IN INFANCY

Background: Transient tachypnea of the newborn (TTN) has rare complications during the acute period and has a good prognosis. In addition it is generally believed that TTN does not lead to any long-term sequelae. However, in limited studies, the frequency of wheezing attacks and asthma was found to be increased in patient who had TTN diagnosis in the neonatal period in comparison to patients who had no respiratory problem in neonatal period. Objectives: The aim of this study was to determine the association between TTN and the development of wheezing in early life. Patients and Methods: This was a prospective study. It included 115 full term infants. It carried out in the NICU of Bab Alsharyia University Hospital. Follow up of all cases after parental consent from February 2017 to July 2018 for 18 month. Where 100 cases complete the follow up with regular assessment in the outpatient clinic for any symptoms of respiratory distress and clinical examination and attacks of wheeze or need for hospital admission, 15 cases missed the study period. Results: Our study revealed that 63 (63%) out of 100 studied cases developed wheezy chest during the follow up period. The studied cases were male gender 35(55.6%) and smoking history especially the father 56 (88.9%) were risk factors for the development of wheeze in the studied cases with statistical significance (p<0.05). There was no statistical significant correlation between wheezy and non-wheezy groups regarding maternal history (bronchial asthma, hypertensive and DM). There was a positive correlation regarding hospital admission 63(100%) after neonatal period in studied cases with statistical significance difference in the wheezy group (P-value of 0.001). Conclusion: The risk factors to developed wheezing symptoms in diagnosed term infant with TTN include male gander, smoking history of father. There is no correlation between maternal bronchial asthma of diagnosed term infant of TTN and development of wheezing symptoms