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2021•World Journal of GastroenterologyOpen access

Early genetic diagnosis of clarithromycin resistance in Helicobacter pylori

Xiaohua Li, Yong-Yi Huang, Linming Lu, Lijuan Zhao, Xian-Ke Luo, Rujia Li, Yuanyuan Dai, Chun Qin, Yan-qiang Huang, Hao Chen

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Abstract

BACKGROUND: strains were isolated from different areas and different populations of Chinese for genomic analysis. AIM: and find the genes for the early diagnosis of clarithromycin resistance. METHODS: increased in the three strains, which was the same in the artificially induced clarithromycin-resistant bacteria. After gene knockout, the drug sensitivity of the strains was assessed. RESULTS: was associated with clarithromycin resistance. CONCLUSION: mutations may be the earliest and most persistent response to clarithromycin resistance, and they may be the potential target genes for the diagnosis, prevention, and treatment of clarithromycin resistance.

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What this paper is about

BACKGROUND: strains were isolated from different areas and different populations of Chinese for genomic analysis. AIM: and find the genes for the early diagnosis of clarithromycin resistance. METHODS: increased in the three strains, which was the same in the artificially induced clarithromycin-resistant bacteria. After gene knockout, the drug sensitivity of the strains was assessed. RESULTS: was associated with clarithromycin resistance. CONCLUSION: mutations may be the earliest and most persistent response to clarithromycin resistance, and they may be the potential target genes for the diagnosis, prevention, and treatment of clarithromycin resistance.

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Available abstract

BACKGROUND: strains were isolated from different areas and different populations of Chinese for genomic analysis. AIM: and find the genes for the early diagnosis of clarithromycin resistance. METHODS: increased in the three strains, which was the same in the artificially induced clarithromycin-resistant bacteria. After gene knockout, the drug sensitivity of the strains was assessed. RESULTS: was associated with clarithromycin resistance. CONCLUSION: mutations may be the earliest and most persistent response to clarithromycin resistance, and they may be the potential target genes for the diagnosis, prevention, and treatment of clarithromycin resistance.

Key concepts: Clarithromycin, Biology, Drug resistance, Gene, Helicobacter pylori, Polymerase chain reaction, Genetics, Microbiology

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