2001•Antimicrobial Agents and ChemotherapyOpen access

Clarithromycin Resistance and Eradication of Helicobacter pylori in Children

Nicolas Kalach, Pierre‐Henri Benhamou, Florence Campeotto, Michel Bergeret, Christophe M. Dupont, Josette Raymond

Abstract

Outcome of Helicobacter pylori infection was analyzed in 61 children treated with a triple therapy including clarithromycin. Bacterial eradication was obtained in all children with clarithromycin-susceptible strains but not in children with clarithromycin-resistant ones (P = 0.0001). H. pylori antimicrobial susceptibility is mandatory before choosing a treatment, and clarithromycin should be avoided in case of resistance.

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Key concepts: Clarithromycin, Helicobacter pylori, Medicine, Helicobacter Infections, Antimicrobial, Antibiotic resistance, Antibacterial agent, Antibiotics