Drug resistance analysis of methicillin resistant S.aureus

Objective To investigate the drug resistance of the meticillin-resistant S.aureus(MRSA) and to provide the reference for clinical reasonable use of drugs.Methods Four hundred and sixty S.aureus strains during the year of 2005-2007 were collected,cultured and identified.The resistance to ten kinds of antimicrobial agents were detected by Disc agar diffusion method and the results were analyzed by WHONET 5.3 software.Results There were 242 MRSA strains(52.61%) and 218 methicillin sensitive staphylococcus aureus(MSSA) strains(47.39%).The resistant rate of MRSA strains to sulfamethoxazole was relatively stable in 71.4%-77.5%.The resistant rates of MRSA strains to erythromycin,clindamycin,gentamicin,levofloxacin,tetracycline and rifampicin were much more higher than those of MSSA strains(P0.001).The resistant rate of MRSA strains to furadantin was higher than that of MSSA(P0.001),but there was no difference to sulfamethoxazole(P0.05).MRSA and MSSA strains all had sensitivity to vancomycin and teicoplanin.Conclusion MRSA has the characteristic of multidrug resistance.Vancomycin is the first drug for infection of MRSA,while nitrofurantoin and sulfamethoxazole may be the second choice.