2021•PubMedOpen access

[Role of interleukin-6 in human umbilical vein endothelial cell to mesenchymal cell transformation].

Ling Guo, Junyong He, Lin Cui, Jintao Mi, S Zhang, Jiabing Sun, Jie Du, Dake Wen, H C Zhang, Jianxin Jiang, J M Wang, Haiyun Huang

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Abstract

After IL-6 treatment, the phenotype and function of HUVECS showed the characteristics of mesenchymal cells in a concentration-dependent manner. The inflammatory factor can promote the process of EndMT, and become one of the important factors regulating the mechanism of tissue fibrosis.

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Key concepts: Mesenchymal stem cell, Umbilical vein, Transformation (genetics), Cell, Cell biology, Immunology, Medicine, Biology