2010•Unpublished venueRequires access

Effect of testosterone on expression of cytokines in endothelial cells

Jing Liu

Abstract

Objective To investigate the effect of testosterone on expression of transforming growth factor-β1(TGF-β1) and hemeoxygenase-1(HO-1)in endothelial cells of human umbilical vein.Methods Effect of testosterone on expression of TGF-β1 and HO-1 in endothelial cells of human umbilical vein was detected by ELISA.Results Testosterone at a physiological concentration of 3.0×10-8mol/L or at an approximately physiological concentration promoted the expression of TGF-β1 and HO-1 in endothelial cells of human umbilical vein in a time-and concentration-dependent manner.Conclusion Testosterone at a physiological concentration or at an approximately physiological concentration promotes the expression of TGF-β1 and HO-1 in endothelial cells of human umbilical vein.

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Key concepts: Umbilical vein, Testosterone (patch), Transforming growth factor, Internal medicine, Endocrinology, Andrology, Human umbilical vein endothelial cell, Biology