Enzymatic activity of liver and kidney altered by the different dose of organophosphate pesticide Malathion in albino rats

Organophosphate pesticides are commonly accepted by the agriculture system in India. Malathion is one of the most usable pesticides in the organophosphate group. It is generally found in the market by the trade name of cythion. In the Indian scenario farmers and occupational works are not aware of the toxic effects of pesticides. Pesticide after entering inside blood comes directly into the liver hence the hepatic system is the main target organ system. Our study is based on the effects of different doses of Malathion pesticide on Enzymatical parameters like blood sGOT, sGPT, alkaline phosphatase, and acid phosphatase. These four parameters indicate the behavior of the liver and kidney of albino rats. We selected four doses of Malathion as 25 mg/kg body weight, 50 mg/kg body weight, 75 mg/kg body weight, and 100 mg/kg body weight per day for 7 days and 15 days of treatment. We find that in normal condition the value of sGOT was 38 + 2.77mg/dl, sGPT 30.25+ 5.09 IU/dl, Acid phosphatase was 2.99 + 1.98 mmol / g/h, and the value of alkaline phosphatase 33.5 +4.98 mol/ g/h with different doses of Malathion after 7 and 15 days the value of sGOT significantly increases up to 44.75 + 5.17mg/dl at the higher dose. The sGOT value significantly increased up to 36.75 + 3.80 IU/dl, the value of Acid phosphatase was increased significantly up to 6.94 + 1.21 mmol/ g/h. and alkaline phosphatase also increased significantly 48.37 + 4.65 mmol/ g/h. The fluctuation in parameters represents the abnormal behavior of the liver and kidney of albino rats due to the toxicity of Malathion.