The E ffects of O rganophosphorus I nsecticides on L iver of M ale M ice

Pesticides cause ecologica l problems which may result in immediate mass mortality and biological magnifications.Objectives: To study the effect of organophosphorus on liver of male mice.Material and Methods: Male Balb/c mice weighing 3 0 - 3 5 gm, 6 0 days old, were treated orally with monocrotophos(1/3 LD 50 ,1.8 mg/kg bw) and methyl parathion (1/ 3 LD 50 ,2.8 mg/kg bw) for 30 days. Th e liver weight, and aminotransferase, acid phosphatase and alkaline phosphatase in homogenates were estimated. Results: The present study revealed the levels of acid phosphatase, alkaline phosphatase, aspartate aminotransferases and alanine aminotransferase s, were significantly ( p<0.05) increased in liver with all of the two organophosphates. Conclusion: It has been concluded that (monocrotophos and methyl parathion) caused increased in the levels of phosphatase and aminotransferase as well as decreased in li ver weight.