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2000•Journal of Analytical ScienceRequires access

Determination of Novalgin by Single-Sweep Oscillopolarography

Wenjun Wu

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Abstract

A method for the determination of novalgin has been described. Novalgin was oxidized by iodine in acidic solution and a sensitive reduction wave of its oxidation product was obstained at-0.76 V ( vs.SCE ) by single sweep oscillopolarography in NH 3·H 2O NH 4Cl buffer solution (pH=11.0). An excellent linear relationship between the peak height and the concentration of novalgin has been found in the range of 0.01～3 μg/mL. The detection limit was 0.005 μg/mL. Furthermore, the polarographic behaviour and the electrode reaction mechanism of its oxidation product were studied. The methods has been applied to the determination of novalgin in tablet with satisfactory results.

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What this paper is about

A method for the determination of novalgin has been described. Novalgin was oxidized by iodine in acidic solution and a sensitive reduction wave of its oxidation product was obstained at-0.76 V ( vs.SCE ) by single sweep oscillopolarography in NH 3·H 2O NH 4Cl buffer solution (pH=11.0). An excellent linear relationship between the peak height and the concentration of novalgin has been found in the range of 0.01～3 μg/mL. The detection limit was 0.005 μg/mL. Furthermore, the polarographic behaviour and the electrode reaction mechanism of its oxidation product were studied. The methods has been applied to the determination of novalgin in tablet with satisfactory results.

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Available abstract

A method for the determination of novalgin has been described. Novalgin was oxidized by iodine in acidic solution and a sensitive reduction wave of its oxidation product was obstained at-0.76 V ( vs.SCE ) by single sweep oscillopolarography in NH 3·H 2O NH 4Cl buffer solution (pH=11.0). An excellent linear relationship between the peak height and the concentration of novalgin has been found in the range of 0.01～3 μg/mL. The detection limit was 0.005 μg/mL. Furthermore, the polarographic behaviour and the electrode reaction mechanism of its oxidation product were studied. The methods has been applied to the determination of novalgin in tablet with satisfactory results.

Key concepts: Chemistry, Polarography, Detection limit, Buffer solution, Iodine, Linear range, Electrode, Peak current

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