Effect of soluble interleukin-13 receptorα2 on inflammatory airway of asthmatic mouse

Objective To investigate the therapeutic potency of soluble interleukin-13 receptorα2(sIL-13Rα2) in asthma and determine the influences of sIL-13Rα2 on airway inflammatory response in sensitized mice. Methods Twenty-four mice were devided randomly into three groups: control group,asthmatic group and sIL-13Rα2 group. Mice in the latter two groups were sensitized and challenged with ovalbumin (OVA) to establish asthmatic models,while mice in control group were treated with saline as the substitution of OVA. Mice in treatment group were injected intraperitoneally with the sIL-13Rα2( 100 μg) 30 min before challenged,while mice in control group and asthmatic group received saline. Histological examinations were undertaken. Cell accounts and IL-13 of the bronchoalveolar lavage fluid were evaluated.Results Compared with control group, total cell and eosinophil number of BA1F, IL-13 in BALF and blood were all increased considerably after OVA challenge (all P ＜0. 001 ＝. The infection of lung issue was significant. Compared with asthmatic group, the above changes was decreased significantly in sIL-13Ra2 group. Conclusions sIL-13Rα2 could significantly alleviate airway inflammation of the asthma mouse. Key words: Soluble interleukin-13 receptorα2; Eosinophil; Asthma; Animal model