Study on pseudomonas aeruginosa with metallo-β-lactamase and its drug resistance in newborn infection

Objective:To understand the infective status of pseudomonas aeruginosa with metallo-β-lactamase and its drug resistance in newborn infection.Methods:After cultivation,the samples were identified by VETEK-32 automatic bacteria system.The incidence of pseudomonas aeruginosa with metallo-β-lactamase was detected by synergy method,the drug resistance of pseudomonas aeruginosa was measured by K-B method.Results:Among 266 strains of pseudomonas aeruginosa,51 strains of pseudomonas aeruginosa were detected with metallo-β-lactamase,the positive rate was 19.17%.The drug resistance rates against piperacillin,ceftazidime,cefoperazone and levofloxacin of metallo-β-lactamase strains were higher than those of non-metallo-β-lactamase strains.The strains producing metallo-β-lactamase had a relative low drug resistance rate against amikacin and partly sensitive to cefoperazone/sulbactam,cefepime and ciprofloxacin.Conclusion:The drug resistance rate of pseudomonas aeruginosa with metallo-β-lactamase increases year by year in newborn infection,the drug resistance rates of metallo-β-lactamase strains and non-metallo-β-lactamase strains against the same drug are different,there is significant difference.More attention should be paid to the detection of pseudomonas aeruginosa with metallo-β-lactamase,which can promote rational use of drug and reduce the incidence of drug resistance.