2009•Intern J Endocrinol MetabRequires access

Bisphosphonate in the treatment of osteogenesis imperfecta

Xi-ran Wang, Pei Yu, Jingtao Dou, Ju-ming Lu

Abstract

Osteogenesis imperfecta (oI) is a genetic disease of connective tissue.The most serous consequences are bone fractures and deformities.90% patients with OI is caused by type I collagen gene mutation.Clinical research indicates that bisphosphonates can inhibit bone resorption,improve bone mass,decrease the incidence of fracture and improve quality of life.Bisphosphonates is an effective treatment for OI.This paper will outline the role of bisphosphonates in mechanism,treatment,effects,side effects and other problems. Key words: Osteogenesis imperfecta; Type I collagen; Bisphosphonate; Treatment

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Key concepts: Osteogenesis imperfecta, Medicine, Bisphosphonate, Bone resorption, Connective tissue, Dentistry, Bone Density Conservation Agents, Osteoporosis