Bisphosphonate in the treatment of osteogenesis imperfecta

Osteogenesis imperfecta(OI) is a heritable disease characterized by bone fragility and reduced bone mass,which can lead to multiple fractures in the patients and result in serious skeletal deformity.Genetic researches have demonstrated that OI mainly resulted from mutations of the genes encoding collagen type Ⅰ.No effective drugs for OI is avmlable previously.However,current clinical studies indicate that bisphosphonate can improve life quality of patients with OI through inhibiting osteoclast-induced bone resorption,increasing bone mineral density,decreasing bone fracture rates,and alleviating pain. Key words: Bisphosphonate; Osteogenesis imperfecta; Treatment