Distribution of HLA-B allele polymorphism of 8962 Han population in Liaoning of China

Objective To investigate the distribution of genetic polymorphism of HLA-B locus in Liaoning Han population. Methods The technique of polymerase chain reaction-sequence specific primers (PCR-SSP) was adopted in genotyping a sample of 8962 unrelated healthy individuals collected from a Chinese Han population in Liaoning area. The allele frequency of HLA-B was calculated and was compared with the results from other population. Results Thirty-four HLA-B alleles were detected. The more common HLA-B allele included B*15(14.42%),B*40(14.33%) and B*13(11.99%). The B*82 and B*83 were absent. Forty-nine HLA-B antigens were detected. Conclusion The HLA-B allele polymorphism distribution of Liaoning Han population exhibits its own characteristic and the difference from old south and north Han population in China.