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[Distribution of HLA-B allele polymorphism of 8962 Han population in Liaoning of China].

Yang Chen, Jianping Li

Open publisher page 5 citations

Abstract

OBJECTIVE: To investigate the distribution of genetic polymorphism of HLA-B locus in Liaoning Han population. METHODS: The technique of polymerase chain reaction-sequence specific primers (PCR-SSP) was adopted in genotyping a sample of 8962 unrelated healthy individuals collected from a Chinese Han population in Liaoning area. The allele frequency of HLA-B was calculated and was compared with the results from other population. RESULTS: Thirty-four HLA-B alleles were detected. The more common HLA-B allele included B*15(14.42%), B*40(14.33%) and B*13(11.99%). The B*82 and B*83 were absent. Forty-nine HLA-B antigens were detected. CONCLUSION: The HLA-B allele polymorphism distribution of Liaoning Han population exhibits its own characteristic and the difference from old south and north Han population in China.

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What this paper is about

OBJECTIVE: To investigate the distribution of genetic polymorphism of HLA-B locus in Liaoning Han population. METHODS: The technique of polymerase chain reaction-sequence specific primers (PCR-SSP) was adopted in genotyping a sample of 8962 unrelated healthy individuals collected from a Chinese Han population in Liaoning area. The allele frequency of HLA-B was calculated and was compared with the results from other population. RESULTS: Thirty-four HLA-B alleles were detected. The more common HLA-B allele included B*15(14.42%), B*40(14.33%) and B*13(11.99%). The B*82 and B*83 were absent. Forty-nine HLA-B antigens were detected. CONCLUSION: The HLA-B allele polymorphism distribution of Liaoning Han population exhibits its own characteristic and the difference from old south and north Han population in China.

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Available abstract

OBJECTIVE: To investigate the distribution of genetic polymorphism of HLA-B locus in Liaoning Han population. METHODS: The technique of polymerase chain reaction-sequence specific primers (PCR-SSP) was adopted in genotyping a sample of 8962 unrelated healthy individuals collected from a Chinese Han population in Liaoning area. The allele frequency of HLA-B was calculated and was compared with the results from other population. RESULTS: Thirty-four HLA-B alleles were detected. The more common HLA-B allele included B*15(14.42%), B*40(14.33%) and B*13(11.99%). The B*82 and B*83 were absent. Forty-nine HLA-B antigens were detected. CONCLUSION: The HLA-B allele polymorphism distribution of Liaoning Han population exhibits its own characteristic and the difference from old south and north Han population in China.

Key concepts: Allele, Genotyping, Allele frequency, Locus (genetics), Genetics, Biology, Human leukocyte antigen, Population

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[Distribution of HLA-B allele polymorphism of 8962 Han population in Liaoning of China]. — Research Paper | ScholarLens