Two cases of pulmonary alveolar proteinosis with literature review

Objective To summarize and analyze the clinical manifestation,pathogenesis,and treatment of pulmonary alveolar proteinosis (PAP).Methods The clinical data of two patients were retrospectively analyzed and the related literatures were reviewed.Results The duration of disease of two patients was more than two years,the clinical manifestation of PAP was characterized by the incompatibility between symptoms signs and radiographs.They were diagnosed by alveolar lavage and transbronchoscopic lung biopsy.After whole lung lavage therapy,blood gas and chest CT scan improved significantly.Conclusions PAP is a rare lung disease,clinical manifestation is not typical.But with the progress of transbronchoscopic lung biopsy technique and alveolar lavage fluid analysis,the found cases had a trend of increasing.Typical chest CT scan showed map,pave stone,and ground glass change.Pathological characteristics is alveolar cavity filling with small granular PAS positive substance.Its pathogenesis is complex,whole lung lavage is the most efficient therapy for PAP at present. Key words: Pulmonary alveolar proteinosis ;  Whole lung lavage