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Influenced of Kojic Acid and β-Cyclodextrin on SPF Value Sunscreen Product Contained Oxybenzone and Octyldimetyl Paba (3:7) (In Vanishing cream base formulation)

Diana Diana, Tristiana Erawati, Widji Soeratri, Noorma Rosita

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Abstract

The aim of this study was to investigate the SPF value of sunscreen product contained oxybenzone and octyl dimetyl PABA (3:7) with the addition of kojic acid 1% w/wr as whitening agent and their complex with p-cyclodextrin in 1:1 molar equivalent. The SPF value was determined by Petro correlation for in vitro method. The result Showed that the addition of kojic acid increased the SPF value of sunscreen product from 10,607 ± 0,432 became 11,741 ± 0,479. A different result showed with the addition of complex form of kojic acid with p-cyclodextrin. The SPF value decreased to 9,113 ± 0,295. The complex formation of the sunscreen agent with p-cyclodextrin was suspected to be responsible for this phenomenon. Moreover, it was suggested to make in vivo correlation with the result of this study.

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What this paper is about

The aim of this study was to investigate the SPF value of sunscreen product contained oxybenzone and octyl dimetyl PABA (3:7) with the addition of kojic acid 1% w/wr as whitening agent and their complex with p-cyclodextrin in 1:1 molar equivalent. The SPF value was determined by Petro correlation for in vitro method. The result Showed that the addition of kojic acid increased the SPF value of sunscreen product from 10,607 ± 0,432 became 11,741 ± 0,479. A different result showed with the addition of complex form of kojic acid with p-cyclodextrin. The SPF value decreased to 9,113 ± 0,295. The complex formation of the sunscreen agent with p-cyclodextrin was suspected to be responsible for this phenomenon. Moreover, it was suggested to make in vivo correlation with the result of this study.

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Available abstract

The aim of this study was to investigate the SPF value of sunscreen product contained oxybenzone and octyl dimetyl PABA (3:7) with the addition of kojic acid 1% w/wr as whitening agent and their complex with p-cyclodextrin in 1:1 molar equivalent. The SPF value was determined by Petro correlation for in vitro method. The result Showed that the addition of kojic acid increased the SPF value of sunscreen product from 10,607 ± 0,432 became 11,741 ± 0,479. A different result showed with the addition of complex form of kojic acid with p-cyclodextrin. The SPF value decreased to 9,113 ± 0,295. The complex formation of the sunscreen agent with p-cyclodextrin was suspected to be responsible for this phenomenon. Moreover, it was suggested to make in vivo correlation with the result of this study.

Key concepts: Kojic acid, Chemistry, Cyclodextrin, Molar ratio, Nuclear chemistry, Phototoxicity, Chromatography, Organic chemistry

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Influenced of Kojic Acid and β-Cyclodextrin on SPF Value Sunscreen Product Contained Oxybenzone and Octyldimetyl Paba (3:7) (In Vanishing cream base formulation) — Research Paper | ScholarLens