Effects of L-carnitine on Blood Lipid Metabolism and Antioxidation in Hyperlipidemia Rats

[Objective] To study the effects of L-carnitine (LC) on lowering the high blood lipid and antioxidation in hyperlipidemia rats. [Method] 50 healthy SD rats were randomly divided into 5 groups. They were fed with standard diet, high-cholesterol diet and high-cholesterol diet with 0.25, 0.5, 1.0 g/(kg·d) LC. After the LC groups were consecutively orally administered LC for 28 days, rat serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) content, as well as super oxide dismutase (SOD) activity and malondialdehyde (MDA) content in serum and liver were determined. [Result] Compared with the high-fat model group, LC could significantly reduce the serum TC, TG, LDL-C levels, increase HDL-C level, and enhance SOD activity in serum and liver, decrease the content of MDA (P0.05). [Conclusion] LC might have a significant role in lowering the high blood lipid and improving internal antioxidant capacity in hyperlipidemia rats.