The therapeutic effects of FLAG regime for refractory and relapsing acute leukemia

Objective To investigate the therapeutic effects of FLAG regimen for refractory and relapsing acute leukemia.Methods Fludarabine 30 mg·m -2 ·d -1 ,3-5 days,Ara-C 1.5 g·m -2 ·d -1 ,5 d and, G-CSF 5μg·kg -1 ·d -1 were used to treat 7 cases (10 times) of refractory and relapsed leukemia.Results Of the 10 times, nine showed response to therapy; one case died of complication. Neutropenia begin at the time of 5-12 days after the regimen initiating and last 5-34 days, thrombocytopenia begin at 5-18 days and last 5-36 days. The adverse reaction includes hyperamino transferase, pyrexia and diarrhea.Conclusion FLAG shows obvious efficts for refractory and relapsing acute leukemia and gains time for hematopoietic stem cell transplantation.