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FLAG Regime Treated for Refractory and Relapsing Acute Leukemia

Haijun Zhao

Abstract

Objective To investigate the therapeutic effect and safety of FLAG(including fludarabin,Ara-c and G-CSF)regimen for refractory or relapsed acute leukemia.Methods 11 cases with refractory or relapsed acute leukemia were treated with FLAG regimen for 1-3 cycles,then observed the therapeutic effects and safety of FLAG regimen.Results In refractory and relapsed patients,complete remission was 57.1%(4/7cases) and 75%(3/4cases),respectively.The overall responsible rate(including the rate of complete and partial remission) was 72.7%(8/11cases).The main adverse reactions were bone marrow inhibition and secondary infection.Conclusion FLAG regimen is an effective and safe therapeutic option for acute promyelycytic leukemia with tolerance of the majority.

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Key concepts: Flag (linear algebra), Medicine, Refractory (planetary science), Regimen, Acute leukemia, Complete remission, Adverse effect, Therapeutic effect