Correlation of serum C-reactive protein levels with insulin resistance in obese hyperglycemic case

Objective To study the relationship between serum C-reactive protein(CRP)levels and insulin resistance(IR)in patients with hyperglycemia and obesity.Methods Fasting plasma glucose(FPG),2h plasma glucose(2hPG),fasting insulin(INS),patient height and weight were measured.Body mass index(BMI)and Homa insulin resistance index(Homa-IR)were calculated.Based on BMI and PG,the participants were divided into 4 groups:normal control group(30 cases),simple obesity group(30 cases),impaired glucose regulation(IGR)obesity group(30 cases)and type 2 diabetic obese group(30 cases).Serum C-reactive protein levels were measured with immunoturbimetric assay.Results(1)CRP and the Homa-IR in other groups were significantly increased comparing with normal control group,with statistical difference observed(P0.001 for all other groups).(2)Comparing with simple obesity group,the CRP and Homa-IR in IGR obesity group and type 2 diabetic obesity group were increased,with statistical difference noted(P0.05 and P0.01 respectively).Comparing with IGR obesity group,the CRP in type 2 diabetic obesity group was significantly increased,with statistical difference observed(P0.001).(3)Correlation analysis showed that Homa-IR was positively correlated with serum CRP(r=0.38,P0.01)and BMI(r=0.26,P0.05).Conclusion Chronic low grade inflammation may exist in the obese crowd,which is closely associated with glycometabolism.