2004•Carcinogenesis,Teratogenesis and MutagenesisRequires access

Effect of Grape Procyanidin on Bcl-2 and Bax Expression of Bone Marrow Cell

Zhong Jin

Abstract

BACKGROUNDAIM: To study the effect of grape procyanidin(GPC)on Bcl_2and Bax expression of the bone marrow cells. MATERIAL AND METHODS: The mice given different dose of GPC were exposed to 60 Co r_rays whole body subacutely.The Bcl_2and Bax expression of mice bone marrow cells was measured by immunohistoˉchemistry method. RESULTS: The expression rates of Bcl_2and Bax of the irradiating control group were10.02%and20.88%respectively,and those of the high dose GPC group were18.28%and16.14%.The differences between the two groups were significant(P0.01). CONCLUSION: GPC can inhibit the abnormal expression of Bcl_2and Bax induced by 60 Coγ-rays radiation.

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Key concepts: Bone marrow, Proanthocyanidin, Apoptosis, Chemistry, Cell, Immunohistochemistry, Molecular biology, Biology