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COMPARATIVE HEPATOPROTECTIVE EFFICACY OF KUMARYASAVA A!D LIVFIT AGAI!ST CARBO! TETRACHLORIDE I!DUCED HEPATIC DAMAGE I! RATS

A Srikanth, Eswar Kumar K, S. K. Mastan, Srinivasa Rao, B Bhavani, Sri Venkateshwara

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Abstract

Summary Livfit and Kumaryasava are polyherbal hepatoprotective formulations used in Indian system of medicine. Livfit and Kumaryasava were evaluated for their hepatoprotective efficacy against carbon tetrachloride (CCl 4) induced hepatic injury in rats. Biochemical parameters like total bilirubin, serum glutamic oxaloacetic transaminases (SGOT), serum glutamic pyruvate transaminases (SGPT) and alkaline phosphatase (ALP) and total proteins were estimated to assess liver function. Silymarin used as reference standard also exhibited hepatoprotective activity against carbon tetrachloride. The biochemical observations were supplemented with histopathological examination of rat liver sections. It was concluded from the study that Livfit has shown more significant hepatoprotective activity against CCl 4 induced hepatic damage in rats.

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Summary Livfit and Kumaryasava are polyherbal hepatoprotective formulations used in Indian system of medicine. Livfit and Kumaryasava were evaluated for their hepatoprotective efficacy against carbon tetrachloride (CCl 4) induced hepatic injury in rats. Biochemical parameters like total bilirubin, serum glutamic oxaloacetic transaminases (SGOT), serum glutamic pyruvate transaminases (SGPT) and alkaline phosphatase (ALP) and total proteins were estimated to assess liver function. Silymarin used as reference standard also exhibited hepatoprotective activity against carbon tetrachloride. The biochemical observations were supplemented with histopathological examination of rat liver sections. It was concluded from the study that Livfit has shown more significant hepatoprotective activity against CCl 4 induced hepatic damage in rats.

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Available abstract

Summary Livfit and Kumaryasava are polyherbal hepatoprotective formulations used in Indian system of medicine. Livfit and Kumaryasava were evaluated for their hepatoprotective efficacy against carbon tetrachloride (CCl 4) induced hepatic injury in rats. Biochemical parameters like total bilirubin, serum glutamic oxaloacetic transaminases (SGOT), serum glutamic pyruvate transaminases (SGPT) and alkaline phosphatase (ALP) and total proteins were estimated to assess liver function. Silymarin used as reference standard also exhibited hepatoprotective activity against carbon tetrachloride. The biochemical observations were supplemented with histopathological examination of rat liver sections. It was concluded from the study that Livfit has shown more significant hepatoprotective activity against CCl 4 induced hepatic damage in rats.

Key concepts: Carbon tetrachloride, Alkaline phosphatase, CCL4, Bilirubin, Liver damage, Liver function, Alanine aminotransferase, Chemistry

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COMPARATIVE HEPATOPROTECTIVE EFFICACY OF KUMARYASAVA A!D LIVFIT AGAI!ST CARBO! TETRACHLORIDE I!DUCED HEPATIC DAMAGE I! RATS — Research Paper | ScholarLens